QuestionWeek 1 quizQuestion 1. The major impact of the physiological changes that occur with aging is:Reduced physiological reserveReduced homeostatic mechanismsImpaired immunological responseAll of the aboveQuestion 2. Men have faster and more efficient biotransformation of drugs and this is thought to be due to:Less obesity rates than womenProstate enlargementTestosteroneLess estrogen than womenQuestion 3. The cytochrome p system involves enzymes that are generally:Inhibited by drugsInduced by drugsInhibited or induced by drugsAssociated with decreased liver perfusionQuestion 4. Functional abilities are best assessed by:Self-report of functionObserved assessment of functionA comprehensive head-to-toe examinationFamily report of functionQuestion 5. Iron Deficiency Anemia (IDA) is classified as a microcytic, hypochromic anemia. This classification refers to which of the following laboratory data?Hemoglobin and HematocritMean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin (MCH)Serum ferritin and serum ironTotal iron binding capacity and transferrin saturationQuestion 6. When interpreting laboratory data, you would expect to see the following in a patient with Anemia of Chronic Disease (ACD):Hemoglobin <12 g/dl, MCV decreased, MCH decreasedHemoglobin >12 g/dl, MCV increased, MCH increasedHemoglobin <12 g/dl, MCV normal, MCH normalHemoglobin >12 g/dl, MCV decreased, MCH increasedQuestion 7. The pathophysiological hallmark of ACD is:Depleted iron storesImpaired ability to use iron storesChronic unable bleedingReduced intestinal absorption of ironQuestion 8. The main focus of treatment of patients with ACD is:Replenishing iron storesProviding for adequate nutrition high in ironManagement of the underlying disorderAdministration of monthly vitamin B12 injectionsQuestion 9. In addition to the complete blood count (CBC) with differential, which of the following laboratory tests is considered to be most useful in diagnosing ACD and IDA?Serum ironTotal iron binding capacityTransferrin saturationSerum ferritinQuestion 10. Symptoms in the initial human immunodeficiency virus (HIV) infection include all of the following except:Sore throatFeverWeight lossHeadacheQuestion 11. Essential parts of a health history include all of the following except:Chief complaintHistory of the present illnessCurrent vital signsAll of the above are essential history componentsQuestion 12.Which of the following clinical reasoning tools is defined as evidence-based resource based on mathematical modeling to express the likelihood of a condition in select situations, settings, and/or patients?Clinical practice guidelineClinical decision ruleClinical algorithmClinical recommendationQuestion 13. The first step in the genomic assessment of a patient is obtaining information regarding:Family historyEnvironmental exposuresLifestyle and behaviorsCurrent medicationsQuestion 14.In autosomal recessive (AR) disorders, individuals need:Only one mutated gene on the sex chromosomes to acquire the diseaseOnly one mutated gene to acquire the diseaseTwo mutated genes to acquire the diseaseTwo mutated genes to become carriersQuestion 15. In AR disorders, carriers have:Two mutated genes; two from one parent that cause diseaseA mutation on a sex chromosome that causes a diseaseA single gene mutation that causes the diseaseOne copy of a gene mutation but not the diseaseQuestion 16. A woman with an X-linked dominant disorder will:Not be affected by the disorder herselfTransmit the disorder to 50% of her offspring (male or female)Not transmit the disorder to her daughtersTransmit the disorder to only her daughtersQuestion 17. According to the Genetic Information Nondiscrimination Act (GINA):Nurse Practitioners (NPs) should keep all genetic information of patients confidentialNPs must obtain informed consent prior to genetic testing of all patientsEmployers cannot inquire about an employee’s genetic informationAll of the aboveQuestion 18. Which of the following would be considered a “red flag” that requires more investigation in a patient assessment?Colon cancer in family member at age 70Breast cancer in family member at age 75Myocardial infarction in family member at age 35All of the aboveQuestion 19. Your 2-year-old patient shows facial features, such as epicanthal folds, up-slanted palpebral fissures, single transverse palmar crease, and a low nasal bridge. These are referred to as:Variable expressivity related to inherited diseaseDysmorphic features related to genetic diseaseDe novo mutations of genetic diseaseDifferent penetrant signs of genetic diseaseQuestion 20.In order to provide a comprehensive genetic history of a patient, the NP should:Ask patients to complete a family history worksheetSeek out pathology reports related to the patient’s disorderInterview family members regarding genetic disordersAll of the above